What Are the Methods of Hormone Replacement?

Modern Options for Personalized Hormone Support

Hormone Replacement Therapy (HRT) continues to evolve with new innovations, delivery methods, and monitoring strategies, providing patients with more control and customization than ever before.

Whether you’re navigating menopause, andropause, or other hormone-related changes, the goal of HRT is to support wellness, balance, and quality of life with approaches tailored to each person’s unique biology.

Note: Hormone therapy should always be supervised by a qualified healthcare provider. Results vary and treatments are not suitable for everyone.

Commonly Used BHRT Delivery Methods

1. Pellet Therapy

• Description: Tiny, bioidentical hormone pellets (typically testosterone, estradiol, or both) are inserted subcutaneously (under the skin), often in the hip area.
• Duration: 3–5 months of continuous release.
• Benefits: Steady hormone levels with minimal daily maintenance.
• Ideal For: Individuals who prefer long-acting, hands-free hormone support.

2. Topical Creams & Gels

• Description: Hormones (estrogen, testosterone, progesterone) are applied to the skin, usually daily.
• Common Forms: Compounded creams, FDA-approved gels, transdermal patches.
• Benefits: Easy to adjust dose; avoids first-pass liver metabolism.
• Considerations: Requires consistent daily application and care to prevent skin transfer to others.

3. Injections (Intramuscular or Subcutaneous)

• Description: Testosterone is administered weekly, bi-weekly, or monthly via injection.
• Benefits: Effective absorption and customizable dosing.
• More clinics offer subcutaneous testosterone, resulting in less discomfort and steadier levels.
• Considerations: Some patients prefer to self-inject at home; others visit clinics for administration.

4. Oral Capsules or Tablets

• Description: Bioidentical or synthetic hormones taken by mouth.
• Types: Micronized progesterone (commonly prescribed), oral estradiol, or compounded blends.
• Benefits: Simple and familiar method for many.
• Considerations: Some forms (especially oral estrogen) may affect liver metabolism or clotting risk in certain individuals — monitoring is key.

5. Transdermal Patches

• Description: Patches worn on the skin (usually lower abdomen or buttocks) that release hormones gradually.
• FDA-approved options available for estrogen and combination therapies.
• Benefits: Convenient, steady dosing; changed weekly or bi-weekly depending on formulation.
• Drawbacks: Skin irritation possible; adherence varies based on body type and activity.

6. Vaginal Applications (for Women)

• Description: Local estrogen creams, tablets, or rings for urogenital support during and after menopause.
• Use: Targets dryness, irritation, or urinary changes without systemic hormone exposure.
• Benefit: Focused relief with minimal systemic absorption.
• Forms: Estradiol creams, DHEA inserts, low-dose vaginal rings.

7. Troches

Description: Small, medicated lozenges that dissolve slowly between the cheek and gum, allowing hormones to absorb directly into the bloodstream.

Benefits:

• Bypasses the digestive tract for better absorption
• Gentle on the stomach
• Flexible dosing and easy adjustments
• Pleasant flavors for comfort

Ideal For: Patients who prefer steady, gradual absorption and a needle-free method.

8. Rapid-Dissolve Tablets

Description: Fast-melting tablets placed on the tongue, designed for quick hormone absorption through oral mucosa.

Benefits:

• Convenient and discreet — no water required
• Absorbs rapidly for faster onset
• Great for travel or busy lifestyles
• Ideal For: Those wanting maximum convenience and quick administration without injections or creams.

What’s New in HRT?

• Expanded Access to Compounded BHRT: More integrative clinics now offer customized hormone blends via 503A/503B pharmacies, with precision dosing and combination therapies.
• Microdosing Trends: Lower-dose, more frequent delivery of hormones (especially testosterone) to reduce peaks and troughs.
• Integrative Add-Ons: Nutraceuticals, adaptogens, and gut-supportive protocols are increasingly included in comprehensive hormone care.

Choosing the Right Method

There’s no one-size-fits-all solution. The right hormone delivery method depends on:

• Your health history and labs
• Lifestyle and preferences (e.g., daily vs. long-acting)
• Sensitivity to ingredients or absorption methods
• Whether you’re addressing systemic symptoms or local support needs

Safety First

HRT should always be approached with:

• Comprehensive lab work and symptom evaluation
• Monitoring of hormone levels, metabolism, and possible side effects
• Regular follow-ups with a licensed provider trained in hormone health

Personalized Support Matters

Modern hormone therapy is more than just replacing what’s low it’s about supporting your whole-body health through thoughtful, individualized care. When used appropriately and monitored closely, HRT can be a valuable tool in restoring a sense of vitality, clarity, and balance.

Curious about your options?
Schedule a consultation to explore which hormone support methods may align with your wellness goals.